Platelets can enhance vascular permeability
نویسندگان
چکیده
منابع مشابه
Platelets can enhance vascular permeability.
Platelets survey blood vessels, searching for endothelial damage and preventing loss of vascular integrity. However, there are circumstances where vascular permeability increases, suggesting that platelets sometimes fail to fulfill their expected function. Human inflammatory arthritis is associated with tissue edema attributed to enhanced permeability of the synovial microvasculature. Murine st...
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1Centre de Recherche en Rhumatologie et Immunologie, Centre de Recherche du Centre Hospitalier Universitaire de Québec, Faculté de Médecine de l’Université Laval, Québec, QC; 2Centre de Recherche du Centre Hospitalier Universitaire de Québec and Department of Molecular Medicine, Université Laval, Québec, QC; 3Department of Biochemistry, University of Cambridge, Cambridge, United Kingdom; 4Unive...
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THE 12-LIPOXYGENASE ENZYME of platelets was the first lipoxygenase to be discovered in animal tissue,1 yet its physiologic significance remains far from clear. The enzyme catalyzes the reaction of arachidonic acid with molecular oxygen to form 12(S)-hydroperoxy-eicosatetraenoic acid (1 2-HPETE); under most conditions the majority of the hydroperoxide is reduced to the hydroxy form (1 2-HETE) an...
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ژورنال
عنوان ژورنال: Blood
سال: 2012
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood-2012-02-413047